Using bacteria to make light sources may soon become possible. A group of students from Newcastle University in the UK are trying to combine electronic engineering and synthetic biology to create "electro-biological" circuits. These students turned genetically modified luminescent E. coli into something like a light bulb. When a bacterium experiences thermal stress from a micro-microbial fuel cell, a device that uses electric energy generated by bacterial activity to act as a battery, the light bulb turns on. The project was unveiled at the International Genetic Engineering Machine Design Competition (iGEM) recently held in Boston, USA. The team designed E. coli that glows due to the increased expression of a fluorescent gene when introduced with a current or heat source at 42°C. They also designed circuits that connect the light bulbs to the power supply in an attempt to create equipment that can be easily assembled like Lego bricks. Although they were unable to allow the fuel cell to activate the bulb during the final round of testing, team member Ollie Burton said that its main goal was to create a toolbox to encourage others to continue research based on the idea. "Everything we do is open source," Burton said. "It's more about what other people can do on the basis of what we set, rather than designing any transformational things ourselves." Jameson Dungan, a synthetic biologist who runs a DIY lab in Norfolk, Va., believes that the project is "just like our first transition from a vacuum tube to a transistor. A transistor does the same thing as a vacuum tube, but in a different way. Like a biological component that recreates the function of an electrical component." Biohackers and DIY scientists have always advocated the idea of ​​open source research. As far as iGEM itself is concerned, it also facilitates communication between laboratories and will establish a standardized, compatible database of "parts" (DNA sequences) for use by teams in trials.
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